The GeNO nitric oxide delivery technology works by passing pre-diluted NO2 gas in O2 or air through a small specially designed chemical reactor operating at ambient temperature called a cartridge. The cartridge, which is the heart of the system, is used to remove an oxygen atom from NO2 and generate pure nitric oxide in O2 or air at the determined therapeutic dose. The purity of the nitric oxide gas in O2 has been tested using a variety of instrumentation techniques. The NO2 level at the exit of the cartridge has been shown to be lower than what is typically present in ambient air.
Paradoxically, although GeNO's nitric oxide delivery systems start with NO2, it delivers nitric oxide to the patient essentially free of the NO2 impurity.